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KMID : 0861020230380050039
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Korea Journal of Herbology
2023 Volume.38 No. 5 p.39 ~ p.47
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Research on vasorelaxant effects of 20 Korean native plants
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Kim Bum-Jung
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Abstract
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Objectives : The objective of present study was to investigate the vasorelaxant effects of 20 Korean native plants on
isolated rat thoracic aorta precontracted with phenylephrine (PE).
Methods : Dried 20 plant materials were extracted 3 times with water, ethanol, or methanol for 3h in the reflux
apparatus at 70 ± 5℃. Male SD rats were anesthetized by ether inhalation, and their aorta rings were isolated and
placed in 10 ㎖ Krebs Henseleit (KH) buffer. While using an isolated organ-chamber technique, the aorta rings were maintained by bubbling with a gas mixture of 95% O2?5% CO2 at 37℃. Changes in isometric tension of aorta rings were recorded via isometric transducers connected to a Powerlab Data Acquisition System.
Results : Among the 20 native plants, Chrysanthemum indicum L. flower, Nelumbo nucifera Gaertn. rhizome, Schisandra
chinensis (Turcz.) Baill. fruit, Anthriscus sylvestris (L.) Hoffm. root, Corydalis turtschaninovii Besser tuber, Corydalis
decumbens (Thunb.) Pers. tuber, and Dolichos lablab L. seed showed significant vasorelaxant effect on the contraction
of aorta rings induced by PE. In contrast, Mertensia maritima subsp. asiatica Takeda whole plant, Ajuga decumbens
Thunb. whole plant, Trigonotis peduncularis (Trevis.) Benth. ex Baker & S.Moore whole plant, Dioscorea quinquelobate
Thunb. rhizome, Allium microdictyon Prokh aerial part, Momordica charantia L. fruit, Carthamus tinctorius L. flower,
and Clematis terniflora DC. root constricted more the aorta rings precontracted by PE
Conclusion : These results suggest that the possibility as useful herbal resources for the development of functional
foods or medicines for hypertension treatment.
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KEYWORD
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native plant, herbal medicine, hypertension, vasorelaxation, vasoconstriction
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